Loss of the retinoblastoma protein-related p130 protein in small cell lung carcinoma.

  title={Loss of the retinoblastoma protein-related p130 protein in small cell lung carcinoma.},
  author={Kristian Helin and Karin Holm and Anita Niebuhr and Hans Eiberg and Niels Tommerup and S Hougaard and Hans Skovgaard Poulsen and Mogens Spang-Thomsen and P Norgaard},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={94 13},
The retinoblastoma gene family consists of the tumor suppressor protein pRB and its two relatives p107 and p130. These proteins have been implicated in the regulation of cell cycle progression, in part, through inactivation of members of the E2F transcription factor family. Overexpression of pRB, p107, or p130 leads to growth arrest in the G1 phase of the cell cycle, and this arrest is abolished by complex formation with the adenovirus E1A, human papilloma virus E7, or simian virus 40 T… CONTINUE READING


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