Loss of the peroxisome proliferation-activated receptor gamma (PPARgamma ) does not affect mammary development and propensity for tumor formation but leads to reduced fertility.

@article{Cui2002LossOT,
  title={Loss of the peroxisome proliferation-activated receptor gamma (PPARgamma ) does not affect mammary development and propensity for tumor formation but leads to reduced fertility.},
  author={Yongzhi K. Cui and Keiko Miyoshi and E. D. Di Claudio and Ulrich K Siebenlist and Frank J. Gonzalez and Jodi Anne Flaws and K M Wagner and Lothar Hennighausen},
  journal={The Journal of biological chemistry},
  year={2002},
  volume={277 20},
  pages={17830-5}
}
The peroxisome proliferation-activated receptor gamma (PPARgamma) is expressed in many cell types including mammary epithelium, ovary, macrophages, and B- and T-cells. PPARgamma has an anti-proliferative effect in pre-adipocytes and mammary epithelial cells, and treatment with its ligands reduced the progression of carcinogen-induced mammary tumors in mice. Because PPARgamma-null mice die in utero it has not been possible to study its role in development and tumorigenesis in vivo. To… CONTINUE READING

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