Loss of the p53/p63 Regulated Desmosomal Protein Perp Promotes Tumorigenesis

Abstract

Dysregulated cell-cell adhesion plays a critical role in epithelial cancer development. Studies of human and mouse cancers have indicated that loss of adhesion complexes known as adherens junctions contributes to tumor progression and metastasis. In contrast, little is known regarding the role of the related cell-cell adhesion junction, the desmosome… (More)
DOI: 10.1371/journal.pgen.1001168

Topics

  • Presentations referencing similar topics