Loss of the innate immunity negative regulator IRAK-M leads to enhanced host immune defense against tumor growth.

@article{Xie2007LossOT,
  title={Loss of the innate immunity negative regulator IRAK-M leads to enhanced host immune defense against tumor growth.},
  author={Qifa Xie and Lu Gan and Jianxia Wang and Ingred Wilson and Liwu Li},
  journal={Molecular immunology},
  year={2007},
  volume={44 14},
  pages={3453-61}
}
IRAK-M is a negative regulator of innate immunity signaling processes. Although attenuation of innate immunity may help to prevent excessive inflammation, it may also lead to compromised immune surveillance of tumor cells and contribute to tumor formation and growth. Here, we demonstrate that IRAK-M(-/-) mice are resistant to tumor growth upon inoculation with transplantable tumor cells. Immune cells from IRAK-M(-/-) mice are responsible for the anti-tumor effect, since adoptive transfer of… CONTINUE READING

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