Loss of the inactive X chromosome and replication of the active X in BRCA1-defective and wild-type breast cancer cells.

@article{Sirchia2005LossOT,
  title={Loss of the inactive X chromosome and replication of the active X in BRCA1-defective and wild-type breast cancer cells.},
  author={Silvia Maria Sirchia and Lisetta Ramoscelli and Francesca Romana Grati and Floriana Barbera and Danila Coradini and Franca Rossella and Giovanni Della Porta and Elena Lesma and A. Ruggeri and Paolo Radice and Giuseppe Simoni and Monica Miozzo},
  journal={Cancer research},
  year={2005},
  volume={65 6},
  pages={2139-46}
}
In females, X chromosome inactivation (XCI) begins with the expression of the XIST gene from the X chromosome destined to be inactivated (Xi) and the coating of XIST RNA in cis. It has recently been reported that this process is supported by the product of the BRCA1 tumor suppressor gene and that BRCA1-/- cancers show Xi chromatin structure defects, thus suggesting a role of XCI perturbation in BRCA1-mediated tumorigenesis. Using a combined genetic and epigenetic approach, we verified the… CONTINUE READING

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