Loss of the imprinted IGF2/cation-independent mannose 6-phosphate receptor results in fetal overgrowth and perinatal lethality.

@article{Lau1994LossOT,
  title={Loss of the imprinted IGF2/cation-independent mannose 6-phosphate receptor results in fetal overgrowth and perinatal lethality.},
  author={Manfred Lau and Charles E Stewart and Zhipei Liu and Harshida Bhatt and Peter Rotwein and Colin Lawson Stewart},
  journal={Genes & development},
  year={1994},
  volume={8 24},
  pages={2953-63}
}
Murine embryos that inherit a nonfunctional insulin-like growth factor-II/cation-independent mannose 6-phosphate receptor (Igf2r) gene from their fathers are viable and develop normally into adults. However, the majority of mice inheriting the same mutated allele from their mothers die around birth, as a consequence of major cardiac abnormalities. These mice do not express IGF2R in their tissues, are 25-30% larger than their normal siblings, have elevated levels of circulating IGF2 and IGF… CONTINUE READING
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