Loss of the high-affinity pentamidine transporter is responsible for high levels of cross-resistance between arsenical and diamidine drugs in African trypanosomes.

@article{Bridges2007LossOT,
  title={Loss of the high-affinity pentamidine transporter is responsible for high levels of cross-resistance between arsenical and diamidine drugs in African trypanosomes.},
  author={Daniel Bridges and Matthew K. Gould and Barbara Nerima and Pascal M{\"a}ser and Richard J. Burchmore and Harry P de Koning},
  journal={Molecular pharmacology},
  year={2007},
  volume={71 4},
  pages={1098-108}
}
Treatment of many infectious diseases is under threat from drug resistance. Understanding the mechanisms of resistance is as high a priority as the development of new drugs. We have investigated the basis for cross-resistance between the diamidine and melaminophenyl arsenical classes of drugs in African trypanosomes. We induced high levels of pentamidine resistance in a line without the tbat1 gene that encodes the P2 transporter previously implicated in drug uptake. We isolated independent… CONTINUE READING

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