Loss of the glycine N-methyltransferase gene leads to steatosis and hepatocellular carcinoma in mice.

@article{MartnezChantar2008LossOT,
  title={Loss of the glycine N-methyltransferase gene leads to steatosis and hepatocellular carcinoma in mice.},
  author={Mar{\'i}a L. Mart{\'i}nez-Chantar and Mercedes V{\'a}zquez-Chantada and Usue Ariz and Nuria E Mart{\'i}nez and Marta Varela and Zigmund Luka and Antonieta Capdevila and Juan Rodr{\'i}guez and Ana M. Aransay and Rune Matthiesen and Heping Yang and Diego F Calvisi and Manel Esteller and Mario F Fraga and Shelly C. Lu and Conrad Wagner and Jose M. Mato},
  journal={Hepatology},
  year={2008},
  volume={47 4},
  pages={1191-9}
}
UNLABELLED Glycine N-methyltransferase (GNMT) is the main enzyme responsible for catabolism of excess hepatic S-adenosylmethionine (SAMe). GNMT is absent in hepatocellular carcinoma (HCC), messenger RNA (mRNA) levels are significantly lower in livers of patients at risk of developing HCC, and GNMT has been proposed to be a tumor-susceptibility gene for liver cancer. The identification of several children with liver disease as having mutations of the GNMT gene further suggests that this enzyme… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 67 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 30 references

Similar Papers

Loading similar papers…