Loss of the ciliary kinase Nek8 causes left-right asymmetry defects.

Abstract

A missense mutation in mouse Nek8, which encodes a ciliary kinase, produces the juvenile cystic kidneys (jck) model of polycystic kidney disease, but the functions of Nek8 are incompletely understood. Here, we generated a Nek8-null allele and found that homozygous mutant mice die at birth and exhibit randomization of left-right asymmetry, cardiac anomalies… (More)
DOI: 10.1681/ASN.2012050490

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