Loss of the cholesterol-binding protein prominin-1/CD133 causes disk dysmorphogenesis and photoreceptor degeneration.

@article{Zacchigna2009LossOT,
  title={Loss of the cholesterol-binding protein prominin-1/CD133 causes disk dysmorphogenesis and photoreceptor degeneration.},
  author={Serena Zacchigna and Hideyasu Oh and Michaela Wilsch-Braeuninger and Ewa Missol-Kolka and J{\'o}zsef J{\'a}szai and Sandra Jansen and Naoyuki Tanimoto and Felix Tonagel and Mathias Seeliger and Wieland B Huttner and Denis Corbeil and Mieke Dewerchin and Stefan Vinckier and Lieve Moons and Peter Carmeliet},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2009},
  volume={29 7},
  pages={2297-308}
}
Prominin-1/CD133 (Prom-1) is a commonly used marker of neuronal, vascular, hematopoietic and other stem cells, yet little is known about its biological role and importance in vivo. Here, we show that loss of Prom-1 results in progressive degeneration of mature photoreceptors with complete loss of vision. Despite the expression of Prom-1 on endothelial progenitors, photoreceptor degeneration was not attributable to retinal vessel defects, but caused by intrinsic photoreceptor defects in disk… CONTINUE READING
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