Loss of the aryl hydrocarbon receptor induces hypoxemia, endothelin-1, and systemic hypertension at modest altitude.

@article{Lund2008LossOT,
  title={Loss of the aryl hydrocarbon receptor induces hypoxemia, endothelin-1, and systemic hypertension at modest altitude.},
  author={Amie K. Lund and Larry N. Agbor and Nan Zhang and Amy Baker and Huawei Zhao and Gregory D. Fink and Nancy Lapp Kanagy and Mary K. Walker},
  journal={Hypertension},
  year={2008},
  volume={51 3},
  pages={803-9}
}
The aryl hydrocarbon receptor (AHR) is a basic helix-loop-helix Per-Arnt-Sim transcription factor that mediates induction of metabolic enzymes and toxicity of certain environmental pollutants. Although AHR knockout (KO) mice develop cardiac hypertrophy, conflicting reports associate this pathology with hypotension or endothelin (ET)-1-dependent hypertension. Because hypertension occurred at modest altitude, we tested the hypothesis that loss of AHR increases the sensitivity to hypoxia-induced… CONTINUE READING
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