Loss of the acyl-CoA binding protein (Acbp) results in fatty acid metabolism abnormalities in mouse hair and skin.

@article{Lee2007LossOT,
  title={Loss of the acyl-CoA binding protein (Acbp) results in fatty acid metabolism abnormalities in mouse hair and skin.},
  author={Lance Lee and C Anthony Debono and Dean R Campagna and David C. Young and D. Branch Moody and Mark D Fleming},
  journal={The Journal of investigative dermatology},
  year={2007},
  volume={127 1},
  pages={16-23}
}
Proper fatty acid metabolism is critical for hair and skin development and maintenance. The acyl-CoA binding protein (Acbp) is a widely expressed protein that binds long-chain fatty acyl-CoA esters and plays a role in fatty acyl-CoA transport and pool formation. However, loss of function of Acbp in the whole animal has not been investigated. Here, we show that deletion of Acbp in mouse results in sebocyte hyperplasia and sparse, matted hair with a greasy appearance. Consistent with these gross… CONTINUE READING

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