Loss of the Par-1b/MARK2 polarity kinase leads to increased metabolic rate, decreased adiposity, and insulin hypersensitivity in vivo.

@article{Hurov2007LossOT,
  title={Loss of the Par-1b/MARK2 polarity kinase leads to increased metabolic rate, decreased adiposity, and insulin hypersensitivity in vivo.},
  author={Jonathan B. Hurov and Mei Huang and L P. Scott White and Jochen K Lennerz and Cheol Soo Choi and Younghak Cho and Hyo-Jeong Kim and Julie L. Prior and David Rolland Piwnica-Worms and Lewis C. Cantley and Jason Kim and Gerald I Shulman and Helen Piwnica-Worms},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2007},
  volume={104 13},
  pages={
          5680-5
        }
}
Obesity is a major factor central to the development of insulin resistance and type 2 diabetes. The identification and characterization of genes involved in regulation of adiposity, insulin sensitivity, and glucose uptake are key to the design and development of new drug therapies for this disease. In this study, we show that the polarity kinase Par-1b/MARK2 is required for regulating glucose metabolism in vivo. Mice null for Par-1b were lean, insulin hypersensitive, resistant to high-fat diet… CONTINUE READING

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