Loss of the Nuclear Receptor Corepressor SLIRP Compromises Male Fertility

Abstract

Nuclear receptors (NRs) and their coregulators play fundamental roles in initiating and directing gene expression influencing mammalian reproduction, development and metabolism. SRA stem Loop Interacting RNA-binding Protein (SLIRP) is a Steroid receptor RNA Activator (SRA) RNA-binding protein that is a potent repressor of NR activity. SLIRP is present in… (More)
DOI: 10.1371/journal.pone.0070700

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