Loss of the Nrf2 transcription factor causes a marked reduction in constitutive and inducible expression of the glutathione S-transferase Gsta1, Gsta2, Gstm1, Gstm2, Gstm3 and Gstm4 genes in the livers of male and female mice.

@article{Chanas2002LossOT,
  title={Loss of the Nrf2 transcription factor causes a marked reduction in constitutive and inducible expression of the glutathione S-transferase Gsta1, Gsta2, Gstm1, Gstm2, Gstm3 and Gstm4 genes in the livers of male and female mice.},
  author={Simon A Chanas and Qing Yan Jiang and Michael McMahon and Gail K McWalter and Lesley I. McLellan and Clifford R. Elcombe and Colin James Henderson and C. R. Wolf and Graeme J Moffat and Ken Ichi Itoh and Masayuki Yamamoto and John D. Hayes},
  journal={The Biochemical journal},
  year={2002},
  volume={365 Pt 2},
  pages={
          405-16
        }
}
Mice that lack the Nrf2 basic-region leucine-zipper transcription factor are more sensitive than wild-type (WT) animals to the cytotoxic and genotoxic effects of foreign chemicals and oxidants. To determine the basis for the decrease in tolerance of the Nrf2 homozygous null mice to xenobiotics, enzyme assay, Western blotting and gene-specific real-time PCR (TaqMan) have been used to examine the extent to which hepatic expression of GSH-dependent enzymes is influenced by the transcription factor… CONTINUE READING

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