Loss of the Lkb1 tumour suppressor provokes intestinal polyposis but resistance to transformation

@article{Bardeesy2002LossOT,
  title={Loss of the Lkb1 tumour suppressor provokes intestinal polyposis but resistance to transformation},
  author={Nabeel Bardeesy and Manisha Sinha and Aram F. Hezel and Sabina Signoretti and Nathaniel A. Hathaway and Norman E Sharpless and Massimo F. Loda and Daniel Ruben Carrasco and Ronald A. Depinho},
  journal={Nature},
  year={2002},
  volume={419},
  pages={162-167}
}
Germline mutations in LKB1 (also known as STK11) are associated with Peutz–Jeghers syndrome (PJS), a disorder with predisposition to gastrointestinal polyposis and cancer. PJS polyps are unusual neoplasms characterized by marked epithelial and stromal overgrowth but have limited malignant potential. Here we show that Lkb1+/- mice develop intestinal polyps identical to those seen in individuals affected with PJS. Consistent with this in vivo tumour suppressor function, Lkb1 deficiency prevents… CONTINUE READING
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