Loss of the Heparan Sulfate Sulfotransferase, Ndst1, in Mammary Epithelial Cells Selectively Blocks Lobuloalveolar Development in Mice

@article{Crawford2010LossOT,
  title={Loss of the Heparan Sulfate Sulfotransferase, Ndst1, in Mammary Epithelial Cells Selectively Blocks Lobuloalveolar Development in Mice},
  author={Brett E Crawford and Omai B. Garner and Joseph R. Bishop and David Y. Zhang and Kevin T Bush and Sanjay K. Nigam and Jeffrey D. Esko},
  journal={PLoS ONE},
  year={2010},
  volume={5}
}
  • Brett E Crawford, Omai B. Garner, +4 authors Jeffrey D. Esko
  • Published 2010
  • Biology, Medicine
  • PLoS ONE
  • Background Considerable evidence indicates that heparan sulfate is essential for the development of tissues consisting of branching ducts and tubules. However, there are few examples where specific sulfate residues regulate a specific stage in the formation of such tissues. Methodology/Principal Findings We examined the role of heparan sulfation in mammary gland branching morphogenesis, lactation and lobuloalveolar development by inactivation of heparan sulfate GlcNAc N-deacetylase/N… CONTINUE READING

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