Loss of tau rescues inflammation-mediated neurodegeneration

@inproceedings{Maphis2015LossOT,
  title={Loss of tau rescues inflammation-mediated neurodegeneration},
  author={Nicole M. Maphis and Guixiang Xu and Olga Nicole Kokiko-Cochran and Astrid E Cardona and Richard M Ransohoff and Bruce T Lamb and Kiran Bhaskar},
  booktitle={Front. Neurosci.},
  year={2015}
}
Neuroinflammation is one of the neuropathological hallmarks of Alzheimer's disease (AD) and related tauopathies. Activated microglia spatially coexist with microtubule-associated protein tau (Mapt or tau)-burdened neurons in the brains of human AD and non-AD tauopathies. Numerous studies have suggested that neuroinflammation precedes tau pathology and that induction or blockage of neuroinflammation via lipopolysaccharide (LPS) or anti-inflammatory compounds (such as FK506) accelerate or block… CONTINUE READING
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