Loss of tau rescues inflammation-mediated neurodegeneration

  title={Loss of tau rescues inflammation-mediated neurodegeneration},
  author={Nicole M. Maphis and Guixiang Xu and Olga Nicole Kokiko-Cochran and Astrid E Cardona and Richard M Ransohoff and Bruce T Lamb and Kiran Bhaskar},
  booktitle={Front. Neurosci.},
Neuroinflammation is one of the neuropathological hallmarks of Alzheimer's disease (AD) and related tauopathies. Activated microglia spatially coexist with microtubule-associated protein tau (Mapt or tau)-burdened neurons in the brains of human AD and non-AD tauopathies. Numerous studies have suggested that neuroinflammation precedes tau pathology and that induction or blockage of neuroinflammation via lipopolysaccharide (LPS) or anti-inflammatory compounds (such as FK506) accelerate or block… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 6 times over the past 90 days. VIEW TWEETS