Loss of stromal caveolin-1 leads to oxidative stress, mimics hypoxia and drives inflammation in the tumor microenvironment, conferring the "reverse Warburg effect": a transcriptional informatics analysis with validation.

@article{Pavlides2010LossOS,
  title={Loss of stromal caveolin-1 leads to oxidative stress, mimics hypoxia and drives inflammation in the tumor microenvironment, conferring the "reverse Warburg effect": a transcriptional informatics analysis with validation.},
  author={Stephanos Pavlides and Aristotelis Tsirigos and Iset Vera and Neal Flomenberg and Philippe G Frank and Mathew C. Casimiro and Chenguang Wang and Paolo M Fortina and Sankar Addya and Richard G. Pestell and Ubaldo e. Martinez-outschoorn and Federica Sotgia and Michael Phillip Lisanti},
  journal={Cell cycle},
  year={2010},
  volume={9 11},
  pages={2201-19}
}
Cav-1 (-/-) deficient stromal cells are a new genetic model for myofibroblasts and cancer-associated fibroblasts. Using an unbiased informatics analysis of the transcriptional profile of Cav-1 (-/-) deficient mesenchymal stromal cells, we have now identified many of the major signaling pathways that are activated by a loss of Cav-1, under conditions of metabolic restriction (with low glucose media). Our informatics analysis suggests that a loss of Cav-1 induces oxidative stress, which mimics a… CONTINUE READING

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