Loss of stimulatory effect of guanosine triphosphate on [(35)S]GTPgammaS binding correlates with Alzheimer's disease neurofibrillary pathology in entorhinal cortex and CA1 hippocampal subfield.

Abstract

Heterotrimeric guanosine triphosphate (GTP)-binding proteins (G-proteins) couple many different cell surface receptor types to intracellular effector mechanisms. Uncoupling between receptors and G-proteins and between G-proteins and adenylyl cyclase (AC) and phospholipase C (PLC) has been described for Alzheimer's disease (AD) brain. However, there is… (More)

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Cite this paper

@article{GarcaJimnez2002LossOS, title={Loss of stimulatory effect of guanosine triphosphate on [(35)S]GTPgammaS binding correlates with Alzheimer's disease neurofibrillary pathology in entorhinal cortex and CA1 hippocampal subfield.}, author={Angel Garc{\'i}a-Jim{\'e}nez and Russel Cowburn and Timothy Ohm and Helen Lasn and Bengt Winblad and Nada Bogdanovi{\'c} and Johan Fastbom}, journal={Journal of neuroscience research}, year={2002}, volume={67 3}, pages={388-98} }