Loss of stearoyl-CoA desaturase activity leads to free cholesterol synthesis through increased Xbp-1 splicing.

@article{Paton2010LossOS,
  title={Loss of stearoyl-CoA desaturase activity leads to free cholesterol synthesis through increased Xbp-1 splicing.},
  author={Chad Michael Paton and James M. Ntambi},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2010},
  volume={299 6},
  pages={E1066-75}
}
Stearoyl-CoA desaturase-1 (SCD-1) is the rate-limiting enzyme in the biosynthesis of monounsaturated fatty acids (MUFA), which are required for efficient neutral lipid esterification. In the present investigation, we demonstrate that loss of SCD-1 activity increases free cholesterol (FC) content and induces Xbp-1 splicing. We assessed the small molecule SCD… CONTINUE READING