Loss of sst2 somatostatin receptor gene expression in human pancreatic and colorectal cancer.

@article{Buscail1996LossOS,
  title={Loss of sst2 somatostatin receptor gene expression in human pancreatic and colorectal cancer.},
  author={Louis Buscail and Nathalie Saint-Laurent and Eric Chastre and J. C. Vaillant and Ch. Gespach and Gabriel Capell{\'a} and Holger Kalthoff and F{\'e}lix Llu{\'i}s and Nicole Vaysse and C. L. Susini},
  journal={Cancer research},
  year={1996},
  volume={56 8},
  pages={1823-7}
}
Five somatostatin receptor subtypes (sst1 to sst5) have been cloned. We demonstrated previously that sst2 and sst5 mediate the antiproliferative effect of the somatostatin analogues octreotide and vapreotide. Using reverse transcription-PCR, we investigated gene expression of the five receptors in 47 human normal and cancerous tissues or cell lines from pancreatic and colorectal origin. mRNAs of somatostatin receptor subtypes were detected in 98% of samples, with more than two mRNA subtypes… CONTINUE READING

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