• Corpus ID: 10063695

Loss of retinoic acid receptors in mouse skin and skin tumors is associated with activation of the ras(Ha) oncogene and high risk for premalignant progression.

@article{Darwiche1996LossOR,
  title={Loss of retinoic acid receptors in mouse skin and skin tumors is associated with activation of the ras(Ha) oncogene and high risk for premalignant progression.},
  author={Nadine Darwiche and Giorgio Scita and C S Jones and Susan E. Rutberg and E Greenwald and Tamar Tennenbaum and Steven J. Collins and Luigi M. De Luca and Stuart H. Yuspa},
  journal={Cancer research},
  year={1996},
  volume={56 21},
  pages={
          4942-9
        }
}
Retinoic acid receptor transcripts (RARalpha and RARgamma) are decreased in benign mouse epidermal tumors relative to normal skin and are almost absent in carcinomas. In this report, the expression of RARalpha and RARgamma proteins was analyzed by immunoblotting in benign skin tumors induced by two different promotion protocols designed to yield tumors at low or high risk for malignant conversion. RARalpha was slightly reduced in papillomas promoted with 12-O-tetradecanoylphorbol-13-acetate… 

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...

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