Loss of retinoic acid receptor-beta expression is an early event during esophageal carcinogenesis.

@article{Qiu1999LossOR,
  title={Loss of retinoic acid receptor-beta expression is an early event during esophageal carcinogenesis.},
  author={Helena Qiu and Wei Zhang and A El-naggar and Scott Michael Lippman and Peizhong Lin and Reuben Lotan and X{\`i}ao-chun Xu},
  journal={The American journal of pathology},
  year={1999},
  volume={155 5},
  pages={1519-23}
}
We recently observed that growth inhibition of esophageal cancer cells by retinoic acid (RA) was associated with both constitutive expression and RA-induced up-regulation of RA receptor beta (RAR-beta). Cell lines that did not express RAR-beta were also resistant to RA. To explore the expression of RAR-beta mRNA in vivo, we analyzed esophageal tissue specimens from 16 normal mucosae, 30 dysplastic lesions, and 157 esophageal tumors by in situ hybridization. RAR-beta was detected in 88% (14/16… CONTINUE READING
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