Loss of reelin expression in breast cancer is epigenetically controlled and associated with poor prognosis.

@article{Stein2010LossOR,
  title={Loss of reelin expression in breast cancer is epigenetically controlled and associated with poor prognosis.},
  author={Torsten Stein and Emilio Cosimo and Xinzi Yu and Paul R. Smith and Ronald Simon and Lorna Cottrell and Marie-Anne Pringle and Alexandra K. Bell and Laura Lattanzio and Guido Sauter and Cristiana Lo Nigro and Timothy Crook and Laura M Machesky and Barry Gusterson},
  journal={The American journal of pathology},
  year={2010},
  volume={177 5},
  pages={2323-33}
}
Reelin is a secreted, signaling protein associated with neuronal cell positioning and migration. Recently, reelin was found to be epigenetically silenced in gastric and pancreatic cancers in which down-regulation was associated with increased migratory ability and reduced survival. Here we analyzed reelin expression by immunohistochemistry in 17 normal breast tissue samples from reduction mammoplasties and in two independent tissue microarrays of 136 and more than 2000 breast cancer biopsy… CONTINUE READING