Loss of rat cerebral cortical opiate receptors following chronic desimipramine treatment.

@article{Reisine1982LossOR,
  title={Loss of rat cerebral cortical opiate receptors following chronic desimipramine treatment.},
  author={Terry David Reisine and Philippe Soubri{\'e}},
  journal={European journal of pharmacology},
  year={1982},
  volume={77 1},
  pages={
          39-44
        }
}
The characteristics of central opiate and beta-adrenergic receptors were studied after giving the tricyclic antidepressant desimipramine (DMI) to rats. Administration of DMI for 1 or 7 days did not alter cortical opiate or beta-adrenergic receptors. However, after 21 days of treatment there was a significant subsensitivity of both these receptors in the cortex. A specific loss of receptor sites for opiate binding was detected with no change in affinity. After a similar time of treatment, opiate… CONTINUE READING
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