Loss of protein phosphatase 1c{gamma} (PPP1CC) leads to impaired spermatogenesis associated with defects in chromatin condensation and acrosome development: an ultrastructural analysis.

@article{Forgione2010LossOP,
  title={Loss of protein phosphatase 1c\{gamma\} (PPP1CC) leads to impaired spermatogenesis associated with defects in chromatin condensation and acrosome development: an ultrastructural analysis.},
  author={Nicole Forgione and A Wayne Vogl and Susannah Varmuza},
  journal={Reproduction},
  year={2010},
  volume={139 6},
  pages={
          1021-9
        }
}
Human male infertility affects approximately 5% of men, with one-third suffering from testicular failure, likely the result of an underlying genetic abnormality that disrupts spermatogenesis during development. Mouse models of male infertility such as the Ppp1cc knockout mouse display very similar phenotypes to humans with testicular failure. Male Ppp1cc mutant mice are sterile due to disruptions in spermatogenesis that begin during prepubertal testicular development, and continue into… CONTINUE READING

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