Loss of protein kinase C delta from human HaCaT keratinocytes upon ras transfection is mediated by TGF alpha.

@article{Geiges1995LossOP,
  title={Loss of protein kinase C delta from human HaCaT keratinocytes upon ras transfection is mediated by TGF alpha.},
  author={D Geiges and Friedrich Marks and Michael Gschwendt},
  journal={Experimental cell research},
  year={1995},
  volume={219 1},
  pages={299-303}
}
The spontaneously immortalized human skin keratinocytes HaCaT contain protein kinase C (PKC) alpha, -delta, -epsilon, and -zeta. All PKC isoenzymes except PKC zeta are down-regulated by TPA as well as by bryostatin. However, with PKC delta, bryostatin but not TPA was found to be much less effective at high concentrations than at low ones. PKC delta expression at the protein and mRNA level is significantly suppressed in HaCaT cells I-7 and II-4, which are transfected with mutated c-Ha-ras. The… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 10 extracted citations

Similar Papers

Loading similar papers…