Loss of promoter methylation contributes to the expression of functionally impaired PRDM1β isoform in diffuse large B-cell lymphoma.

@article{Zhang2010LossOP,
  title={Loss of promoter methylation contributes to the expression of functionally impaired PRDM1β isoform in diffuse large B-cell lymphoma.},
  author={Yi-wen Zhang and Hong-Qiang Xie and Yu Chen and B W Jiao and Zhi-xiang Shen and Sai-juan Chen and Wei-Li Zhao},
  journal={International journal of hematology},
  year={2010},
  volume={92 3},
  pages={439-44}
}
The positive regulatory domain I (PRDM1) is a transcriptional repressor that plays an important role in the B-cell differentiation. PRDM1β isoform is functionally impaired and overexpressed in a subset of diffuse large B-cell lymphoma with aggressive behavior. To investigate the possible epigenetic alteration on PRDM1β expression, methylation of PRDM1β promoter was assessed in B-lymphoma cell lines by bisulfite-sequencing PCR and screened in tumor samples of DLBCL patients using MassARRAY… CONTINUE READING

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