Loss of proliferative capacity and induction of senescence in oxidatively stressed human fibroblasts.

@article{Chen2004LossOP,
  title={Loss of proliferative capacity and induction of senescence in oxidatively stressed human fibroblasts.},
  author={Jian-hua Chen and Kai Stoeber and Sarah R Kingsbury and Susan E Ozanne and Gareth Haydn Williams and Charles Nicholas Hales},
  journal={The Journal of biological chemistry},
  year={2004},
  volume={279 47},
  pages={49439-46}
}
Cellular senescence can result from short, dysfunctional telomeres, oxidative stress, or oncogene expression, and may contribute to aging. To investigate the role of cellular senescence in aging it is necessary to define the time-dependent molecular events by which it is characterized. Here we investigated changes in levels of key proteins involved in cell cycle regulation, DNA replication, and stress resistance in senescing human fibroblasts following oxidative stress. An immediate response in… CONTINUE READING

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