Loss of progesterone receptor links to high proliferation and increases from primary to metastatic endometrial cancer lesions.

@article{Tangen2014LossOP,
  title={Loss of progesterone receptor links to high proliferation and increases from primary to metastatic endometrial cancer lesions.},
  author={Ingvild L\oberg Tangen and Henrica M. J. Werner and Anna Berg and Mari Kylles\o Halle and Kanthida Kusonmano and Jone Trovik and Erling Andre Hoivik and Gordon B. Mills and Camilla Krakstad and Helga Birgitte Salvesen},
  journal={European journal of cancer},
  year={2014},
  volume={50 17},
  pages={3003-10}
}
OBJECTIVE In endometrial cancer loss of progesterone receptor (PR, gene name PGR) is associated with aggressive disease and altered response to hormonal treatment. The aim of this study was to investigate changes in PR expression level with disease progression, and explore whether differences in gene expression according to PR status can be linked to processes involved in cancer development elucidating new therapeutic opportunities. METHODS 686 primary endometrial cancers and 171 metastatic… CONTINUE READING