Loss of profilin-1 expression enhances breast cancer cell motility by Ena/VASP proteins.

  title={Loss of profilin-1 expression enhances breast cancer cell motility by Ena/VASP proteins.},
  author={Yong Ho Bae and Zhijie Ding and Li Zou and Alan Wells and Frank B. Gertler and Partha Roy},
  journal={Journal of cellular physiology},
  volume={219 2},
We previously showed that silencing profilin-1 (Pfn1) expression increases breast cancer cell motility, but the underlying mechanisms have not been explored. Herein, we demonstrate that loss of Pfn1 expression leads to slower but more stable lamellipodial protrusion thereby enhancing the net protrusion rate and the overall motility of MDA-MB-231 breast cancer cells. Interestingly, MDA-MB-231 cells showed dramatic enrichment of VASP at their leading edge when Pfn1 expression was downregulated… CONTINUE READING


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