Loss of phospholipase D2 impairs VEGF-induced angiogenesis

@inproceedings{Lee2016LossOP,
  title={Loss of phospholipase D2 impairs VEGF-induced angiogenesis},
  author={Chang Sup Lee and Jaewang Ghim and Parkyong Song and Pann-Ghill Suh and Sung Ho Ryu},
  booktitle={BMB reports},
  year={2016}
}
Vascular endothelial growth factor (VEGF) is a key mediator of angiogenesis and critical for normal embryonic development and repair of pathophysiological conditions in adults. Although phospholipase D (PLD) activity has been implicated in angiogenic processes, its role in VEGF signaling during angiogenesis in mammals is unclear. Here, we found that silencing of PLD2 by siRNA blocked VEGF-mediated signaling in immortalized human umbilical vein endothelial cells (iHUVECs). Also, VEGF-induced… CONTINUE READING

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