Loss of peroxisomal enzyme expression in preneoplastic and neoplastic lesions induced by peroxisome proliferators in rat livers.

@article{Yokoyama1992LossOP,
  title={Loss of peroxisomal enzyme expression in preneoplastic and neoplastic lesions induced by peroxisome proliferators in rat livers.},
  author={Yoshihito Yokoyama and Shigeki Tsuchida and Ichiro Hatayama and Kimihiko Satoh and Toshiharu Narita and M. Sambasiva Rao and Janardan K. Reddy and Junji Yamada and Tetsuya Suga and Kiyomi Sato},
  journal={Carcinogenesis},
  year={1992},
  volume={13 2},
  pages={265-9}
}
Immunohistochemical staining of enoyl CoA hydratase (ECH), a key peroxisomal enzyme, revealed that the putative preneoplastic lesions induced in livers by administration of the peroxisome proliferator (PP) clofibrate (0.3% in diet) to rats for 60 weeks or more, lacked this enzyme so that they could be detected as ECH-negative foci. ECH and other peroxisomal enzymes such as acyl CoA oxidase, catalase and carnitine-dependent acetyltransferase were also either not or only weakly expressed in most… CONTINUE READING

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