Loss of penicillinase plasmids of Staphylococcus aureus after treatment with L-ascorbic acid.

@article{Cuevas1988LossOP,
  title={Loss of penicillinase plasmids of Staphylococcus aureus after treatment with L-ascorbic acid.},
  author={C F Am{\'a}bile Cuevas},
  journal={Mutation research},
  year={1988},
  volume={207 3-4},
  pages={107-9}
}
When 2 clinical strains of plasmid-mediated penicillin-resistant Staphylococcus aureus were treated with 1 mM sodium ascorbate for 6 h, 12-35% colony-forming units (CFU) irreversibly lost their ability to produce beta-lactamase. Agarose gel electrophoresis showed the disappearance of the plasmid bands from the lysates of colonies in which susceptibility to penicillin was induced by ascorbate treatment. Since ascorbic acid is a compound that is completely non-toxic, the possibility of its… CONTINUE READING