Loss of penicillin tolerance by inactivating the carbon catabolite repression determinant CcpA in Streptococcus gordonii.

@article{Bizzini2007LossOP,
  title={Loss of penicillin tolerance by inactivating the carbon catabolite repression determinant CcpA in Streptococcus gordonii.},
  author={Alain Bizzini and Jos{\'e} Manuel Entenza and Philippe Moreillon},
  journal={The Journal of antimicrobial chemotherapy},
  year={2007},
  volume={59 4},
  pages={607-15}
}
OBJECTIVES Antibiotic tolerance is a phenomenon allowing bacteria to withstand drug-induced killing. Here, we studied a penicillin-tolerant mutant of Streptococcus gordonii (Tol1), which was shown to be deregulated in the expression of the arginine deiminase operon (arc). arc was not directly responsible for tolerance, but is controlled by the global regulator CcpA. Therefore, we sought whether CcpA might be implicated in tolerance. METHODS The ccpA gene was characterized and subsequently… CONTINUE READING
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