Loss of p73 gene expression in lymphoid leukemia cell lines is associated with hypermethylation.

@article{Liu2001LossOP,
  title={Loss of p73 gene expression in lymphoid leukemia cell lines is associated with hypermethylation.},
  author={Meigen Liu and Takeshi Taketani and Rongsheng Li and Junko Takita and Takao Taki and Hao W Yang and Haruko Kawaguchi and Kohmei Ida and Yoshinobu Matsuo and Yutaka Hayashi},
  journal={Leukemia research},
  year={2001},
  volume={25 6},
  pages={441-7}
}
The expression of the p73 gene and the methylation status was examined in 61 acute lymphoblastic leukemia (ALL) cell lines and lymphocytes from seven healthy individuals. p73 mRNA was not expressed in 19 (31.1%) of 61 ALL cell lines, including 11 (31.4%) of 35 B-precursor ALL cell lines, 2 (16.7%) of 12 B-ALL/Burkitt lymphoma (BL) cell lines (totally 27.7% of B-lineage cell lines), 6 (42.9%) of 14 T-ALL cell lines, and expressed in all of normal lymphocytes, by reverse transcriptase-polymerase… CONTINUE READING