Loss of p73 expression in six non-small cell lung cancer cell lines is associated with 5'CpG island methylation.

@article{Liu2008LossOP,
  title={Loss of p73 expression in six non-small cell lung cancer cell lines is associated with 5'CpG island methylation.},
  author={Kaishan Liu and Meiyi Zhan and Peie Zheng},
  journal={Experimental and molecular pathology},
  year={2008},
  volume={84 1},
  pages={59-63}
}
P73 is located on chromosome 1p36, a region that is frequently deleted in neuroblastoma and other tumors. P73 has been postulated to be a candidate tumor suppressor and imprinted gene that shares significant homology with the p53 gene. To investigate the pattern of inactivation of this gene in human non-small cell lung cancers, we studied the six NSCLC cell lines to identify abnormal methylation in exon 1 and the allelic expression using StyI polymorphism analysis. We also examined the p73 gene… CONTINUE READING
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