Loss of p53 promotes RhoA–ROCK-dependent cell migration and invasion in 3D matrices

@article{Gadea2007LossOP,
  title={Loss of p53 promotes RhoA–ROCK-dependent cell migration and invasion in 3D matrices},
  author={Gilles Gadea and Marion de Toledo and C. Anguille and Pierre Roux},
  journal={The Journal of Cell Biology},
  year={2007},
  volume={178},
  pages={23 - 30}
}
In addition to its role in controlling cell cycle progression, the tumor suppressor protein p53 can also affect other cellular functions such as cell migration. In this study, we show that p53 deficiency in mouse embryonic fibroblasts cultured in three-dimensional matrices induces a switch from an elongated spindle morphology to a markedly spherical and flexible one associated with highly dynamic membrane blebs. These rounded, motile cells exhibit amoeboid-like movement and have considerably… CONTINUE READING

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