Loss of p53 compensates for alpha v-integrin function in retinal neovascularization.

@article{Strmblad2002LossOP,
  title={Loss of p53 compensates for alpha v-integrin function in retinal neovascularization.},
  author={Staffan Str{\"o}mblad and Arun Fotedar and Howard Brickner and Chandra L. Theesfeld and Edith Aguilar de Diaz and Martin Friedlander and David A. Cheresh},
  journal={The Journal of biological chemistry},
  year={2002},
  volume={277 16},
  pages={13371-4}
}
alpha(v)-Integrin antagonists block neovascularization in various species, whereas 20% of alpha(v)-integrin null mice are born with many normal looking blood vessels. Given that blockade of alpha(v)-integrins during angiogenesis induces p53 activity, we utilized p53 null mice to elucidate whether loss of p53 can compensate for alpha(v)-integrin function in… CONTINUE READING