Loss of p53 and acquisition of angiogenic microRNA profile are insufficient to facilitate progression of bladder urothelial carcinoma in situ to invasive carcinoma.

@article{Pea2011LossOP,
  title={Loss of p53 and acquisition of angiogenic microRNA profile are insufficient to facilitate progression of bladder urothelial carcinoma in situ to invasive carcinoma.},
  author={Francisco Ayala de la Pe{\~n}a and Keizo Kanasaki and Megumi Kanasaki and Neelima Tangirala and Genta Maeda and Raghu Kalluri},
  journal={The Journal of biological chemistry},
  year={2011},
  volume={286 23},
  pages={20778-87}
}
Activation of oncogenes or inactivation of tumor suppressors in urothelium is considered critical for development of urothelial cancer. Here we report cloning of the urothelium-specific promoter uroplakin-II (UPK II) and generation of transgenic mice in which expression of SV40 large T antigen is driven by UPK II promoter. Inactivation of tumor suppressor p53 and pRb in urothelium by SV40 T antigen resulted in urothelial carcinoma, resembling human high-grade carcinoma in situ. Specific… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 31 extracted citations

References

Publications referenced by this paper.

hp://w w w .jb.org/ D

  • M. Yamakuchi, C. D. Lotterman, +5 authors C. J. Lowenstein
  • Proc Natl Acad Sci U S A 107,
  • 2009

Similar Papers

Loading similar papers…