Loss of p53 and Ink4a/Arf cooperate in a cell autonomous fashion to induce metastasis of hepatocellular carcinoma cells.

@article{Chen2007LossOP,
  title={Loss of p53 and Ink4a/Arf cooperate in a cell autonomous fashion to induce metastasis of hepatocellular carcinoma cells.},
  author={Ya-Wen Chen and David S. Klimstra and Michelle E. Mongeau and Jessica L. Tatem and Victor Boyartchuk and Brian C. Lewis},
  journal={Cancer research},
  year={2007},
  volume={67 16},
  pages={7589-96}
}
Hepatocellular carcinoma (HCC) is a leading cause of cancer-related death worldwide. HCC patients frequently present with disease that has metastasized to other regions of the liver, the portal vein, lymph nodes, or lungs, leading to poor prognoses. Therefore, model systems that allow exploration of the molecular mechanisms underlying metastasis in this disease are greatly needed. We describe here a metastatic HCC model generated after the somatic introduction of the mouse polyoma virus middle… CONTINUE READING

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