Loss of p16 expression is of prognostic significance in locally advanced prostate cancer: an analysis from the Radiation Therapy Oncology Group protocol 86-10.

@article{Chakravarti2003LossOP,
  title={Loss of p16 expression is of prognostic significance in locally advanced prostate cancer: an analysis from the Radiation Therapy Oncology Group protocol 86-10.},
  author={Arnab Chakravarti and Kateri H Heydon and Christopher L. Wu and Elizabeth M Hammond and Alan Pollack and Mack Roach and Harvey B Wolkov and Paul Okunieff and J M Cox and James Fontanesi and Ross Allen Abrams and Miljenko V Pilepich and William Shipley},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  year={2003},
  volume={21 17},
  pages={3328-34}
}
PURPOSE The retinoblastoma (RB) cell cycle regulatory pathway is known to be deregulated in virtually all known human tumors. The protein product of the RB gene, pRB, and its upstream regulator, p16, are among the most commonly affected members of this pathway. We investigated the prognostic significance of both pRB and p16 expression in locally advanced prostate cancers, from patients treated on the Radiation Therapy Oncology Group (RTOG) protocol 86-10. MATERIALS AND METHODS Sixty-seven… CONTINUE READING
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