Loss of p16 expression has prognostic significance in human nasopharyngeal carcinoma.

  title={Loss of p16 expression has prognostic significance in human nasopharyngeal carcinoma.},
  author={Antti Aarni M{\"a}kitie and Christina Macmillan and James Ho and Wei Shi and Andrew Go Lee and Brian O'Sullivan and David Payne and Melania Pintilie and Bernard J. Cummings and John Waldron and Padraig Richard Warde and Jonathan C. Irish and Dale Brown and Ralph Gilbert and Patrick J. Gullane and Fei-fei Liu and Suzanne Kamel-Reid},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  volume={9 6},
PURPOSE p16 is an important inhibitor of cell cycle progression; absence of p16 can thus result in increased cellular proliferation. In nasopharyngeal carcinoma (NPC), absence of p16 has been reported in association with presence of the EBV and pRb. We therefore examined p16, pRb, and EBV-encoded RNA (EBER) expression in biopsy specimens from 84 patients with newly diagnosed NPC, who were treated primarily with curative radiation therapy. Our objective was to determine whether there was a… CONTINUE READING
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