Loss of p14ARF in tumor cells facilitates replication of the adenovirus mutant dl1520 (ONYX-015)

@article{Ries2000LossOP,
  title={Loss of p14ARF in tumor cells facilitates replication of the adenovirus mutant dl1520 (ONYX-015)},
  author={Stefan J. Ries and Christian H. Brandts and Alicia S. Chung and Carola H. Biederer and Byron Hann and Ettie M. Lipner and Frank Mccormick and W. Michael Korn},
  journal={Nature Medicine},
  year={2000},
  volume={6},
  pages={1128-1133}
}
The adenovirus mutant dl1520 (ONYX-015) does not express the E1B-55K protein that binds and inactivates p53. This virus replicates in tumor cells with mutant p53, but not in normal cells with functional p53. Although intra-tumoral injection of dl1520 shows promising responses in patients with solid tumors, previous in vitro studies have not established a close correlation between p53 status and dl1520 replication. Here we identify loss of p14ARF as a mechanism that allows dl1520 replication in… CONTINUE READING

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