Loss of p 120 catenin and links to mitotic alterations , inflammation , and skin cancer

@inproceedings{PerezMoreno2008LossOP,
  title={Loss of p 120 catenin and links to mitotic alterations , inflammation , and skin cancer},
  author={Mirna Perez-Moreno and Weimin Song and Hilda Amalia Pasolli and Scott E Williams and Elaine Fuchs},
  year={2008}
}
Tumor formation involves epigenetic modifications and microenvironmental changes as well as cumulative genetic alterations encompassing somatic mutations, loss of heterozygosity, and aneuploidy. Here, we show that conditional targeting of p120 catenin in mice leads to progressive development of skin neoplasias associated with intrinsic NFB activation. We find that, similarly, squamous cell carcinomas in humans display altered p120 and activated NFB. We show that epidermal hyperproliferation… CONTINUE READING