Loss of osteopontin perturbs the epithelial-mesenchymal transition in an injured mouse lens epithelium

@article{Saika2007LossOO,
  title={Loss of osteopontin perturbs the epithelial-mesenchymal transition in an injured mouse lens epithelium},
  author={Shizuya Saika and Kumi Shirai and Osamu Yamanaka and Ken-ichi Miyazaki and Yuka Okada and Ai Kitano and Kathleen C. Flanders and Shigeyuki Kon and Toshimitsu Uede and Winston Whei-Yang Kao and Susan R. Rittling and David T. Denhardt and Yoshitaka Ohnishi},
  journal={Laboratory Investigation},
  year={2007},
  volume={87},
  pages={130-138}
}
We previously reported that osteopontin (OPN), a matrix structural glycophosphoprotein, is upregulated in the injured mouse lens prior to the epithelial–mesenchymal transition (EMT). Here, we investigated the role of this protein in EMT of the lens epithelium during wound healing. The crystalline lens was injured by needle puncture in OPN-null (KO, n=40) and wild-type (WT, n=40) mice. The animals were killed at day 1, 2, 5, and 10 postinjury. Immunohistochemistry was employed to detect α-smooth… CONTINUE READING

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