Loss of osteocyte integrity in association with microdamage and bone remodeling after fatigue in vivo.

@article{Verborgt2000LossOO,
  title={Loss of osteocyte integrity in association with microdamage and bone remodeling after fatigue in vivo.},
  author={Olivier Verborgt and Gary J. Gibson and Mitchell B. Schaffler},
  journal={Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research},
  year={2000},
  volume={15 1},
  pages={60-7}
}
As a result of fatigue, bone sustains microdamage, which is then repaired by bone-remodeling processes. How osteoclastic activity is targeted at the removal of microdamaged regions of bone matrix is unknown. In the current studies, we tested the hypothesis that changes in osteocyte integrity, through the initiation of regulated cell death (apoptosis), are associated with fatigue-related microdamage and bone resorption. Ulnae of adult rats were fatigue-loaded to produce a known degree of matrix… CONTINUE READING

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