Loss of orphan receptor germ cell nuclear factor function results in ectopic development of the tail bud and a novel posterior truncation.

@article{Chung2001LossOO,
  title={Loss of orphan receptor germ cell nuclear factor function results in ectopic development of the tail bud and a novel posterior truncation.},
  author={Arthur C-K Chung and David B. Katz and Fred A Pereira and Kathy J Jackson and Francesco J. Demayo and Austin John Cooney and Bert W. O'malley},
  journal={Molecular and cellular biology},
  year={2001},
  volume={21 2},
  pages={663-77}
}
The dynamic embryonic expression of germ cell nuclear factor (GCNF), an orphan nuclear receptor, suggests that it may play an important role during early development. To determine the physiological role of GCNF, we have generated a targeted mutation of the GCNF gene in mice. Germ line mutation of the GCNF gene proves that the orphan nuclear receptor is essential for embryonic survival and normal development. GCNF(-/-) embryos cannot survive beyond 10.5 days postcoitum (dpc), probably due to… CONTINUE READING