Loss of oriented cell division does not initiate cyst formation.

@article{Nishio2010LossOO,
  title={Loss of oriented cell division does not initiate cyst formation.},
  author={Saori Nishio and Xin Tian and Anna Rachel Gallagher and Zhiheng Yu and Vishal Patel and Peter Igarashi and Stefan Somlo},
  journal={Journal of the American Society of Nephrology : JASN},
  year={2010},
  volume={21 2},
  pages={295-302}
}
Polycystic kidney disease (PKD) can arise from either developmental or postdevelopmental processes. Recessive PKD, caused by mutations in PKHD1, is a developmental defect, whereas dominant PKD, caused by mutations in PKD1 or PKD2, occurs by a cellular recessive mechanism in mature kidneys. Oriented cell division is a feature of planar cell polarity that describes the orientation of the mitotic axes of dividing cells during development with respect to the luminal vector of the elongating nephron… CONTINUE READING

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